A large clinical trial led by researchers at Karolinska Institutet, Karolinska University Hospital and SciLifeLab shows that low-dose aspirin can reduce the risk of stage I–III colorectal cancer relapse by about 50%. The results are published in The New England Journal of Medicine (NEJM)

Aspirin halves recurrence in colorectal cancers

In a recently published study in Science, researchers at the Royal Swedish Academy of Sciences and Stockholm University show that fungi, just like humans, separate their germ cells early in their development. These new and unexpected findings change our understanding of how evolution works among fungi.

Evolution of fungi in a study of fairy rings

SciLifeLab researchers have developed a new tool called AF_unmasked, designed to overcome the limitations of AlphaFold when predicting large and flexible protein complex structures. The new tool was published in Nature Communications the same day that the creators of AlphaFold were awarded the Nobel Prize in Chemistry. Read the full story at [SciLifeLab news](https://www.scilifelab.se/news/new-scilifelab-developed-tool-overcomes-prediction-limitations-of-nobel-prize-winning-alphafold/)


New tool enhancing Nobel Prize-winning AlphaFold

Spider major ampullate silk fiber, which is used as a safety line, is renowned for its remarkable strength and flexibility, yet the exact mechanisms behind its production remain largely unknown. A new study by Anna Rising’s lab has provided novel insights into the production and composition of this fascinating material.

Multi-omics reveal spider silk fiber composition

ProBio is a clinical trial project lead by Professor Johan Lindberg, Scilifelab and Karolinska Institute, with collaboration with Scilifelab Clinical Genomics and NBIS (run as a NBIS Partner Project). As a side effect, the project has previously yielded routine diagnostic testing of cell-free DNA for patients with metastatic prostate cancer at Karolinska Hospital. The first results from this trial have now been published in Nature Medicine.

Precision medicine: results from ProBio trial

Spearpoint Analytics has used the AI compute and data sharing services at the NBIS infrastructure unit AIDA Data Hub to improve the diagnostic tools available for prostate cancer using AI and machine learning.

The startup company Spearpoint Analytics develops an outcome-based analysis (PCAI – Prostate Cancer Aggressiveness Index) that predicts the severity of prostate cancer by analyzing microscopy images of tissue sections.

AI grading of prostate cancer

Karolinska University Hospital in Sweden now offers routine diagnostic testing of cell-free DNA in patients with metastatic prostate cancer. Researchers at Karolinska Institutet and SciLifeLab developed the test, now also available to hospitals across the Nordic region, potentially broadening treatment options for more patients with mutations in certain genes.

Precision medicine test for prostate cancer

A new bioinformatics pipeline, called GenErode, has been created by a group of researchers from the SciLifeLab National Bioinformatics Infrastructure (NBIS) and the Swedish Museum of Natural History and Stockholm University. The new pipeline may become very important for conservation experts and addresses a fundamental limitation within the field of genomic studies on endangered species.

GenErode, conservation of endangered species

The infrastructure at SciLifeLab is a prerequisite for Key2Brain’s operations. The start-up company Key2Brain develops small antibody fragments which, when coupled with other proteins or drugs, can cross the blood-brain barrier and reach target molecules inside the brain. The goal is improved treatment for patients suffering from brain diseases. The company currently has projects in preclinical phase. 

Industry case: Key2Brain’s, Antibody Fragments

Researchers at Stockholm University, in collaboration with NBIS bioinformaticians, have revealed the architecture and evolution of a supergene behind efficient cross-pollination, and thus, solved a more than century old mystery.
 
The study, published in Current Biology, demonstrate the exceptional power of evolution and its ability to find convergent solutions, such as highly efficient cross-pollinating mechanisms.

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