During my PhD studies and postdoc, I have been interested in the non-coding genome, with a particular focus on Transposable Elements (TEs) and Long non-coding RNAs (lncRNAs). I have developed novel pipelines to study the biological function and define the targets of a new class of circular non-coding RNA as well as understanding the impact of TEs in the evolution of genomes and the nervous system. In particular, I studied the evolutionary relationship between TEs and gene clusters by analyzing the TEs enrichment of specific gene clusters in species selected from different phyla and at different levels of complexity. I also developed bioinformatics pipelines to assemble full-length TEs in Whole Genome Sequencing (WGS) data and evaluate their activity in the brain of a marine non-model organism such as the octopus.