* The GoE project was initiated in response to the rapidly growing use of genetic data in research and clinical applications, and the lack of a whole genome sequence (WGS) reference dataset for Europe.
* The project brings together the ambitions of the [1+MG](https://digital-strategy.ec.europa.eu/en/policies/1-million-genomes) initiative, the legal and technical framework developed by the [GDI](https://gdi.onemilliongenomes.eu/) (Genomic Data Infrastructure) and genomic data providers to deliver a resourceful database for research and future clinical applications.    
* The Genome of Europe (GoE) kick-off meeting took place on 30—31 October in Rotterdam, the Netherlands. 

**27 countries join forces to establish a unique pan-European reference database comprising of a minimum of 100,000 genomes representative of European citizens**

The most extensive EU-funded program on population genomics to date, “Genome of Europe” (GoE), has officially launched. The project partners convened in Rotterdam on 30 - 31. October to launch the largest EU program on population genomics in Europe called “Genome of Europe” (GoE). During the next 42 months this groundbreaking initiative will establish a unique pan-European reference database of at least 100,000 genomes to generate the reference genome through integration of genome datasets from diverse national populations – all for the benefit of personalised health care. The reference database will represent Europe’s diverse populations, integrating existing genomic datasets and new genomic data through de novo sequencing of distinct national populations. The project encompasses 49 partners across 27 European countries (26 EU + 1 non-EU) and is backed by €45 million in funding with 20 million coming from the EU under the Digital Europe Programme by the European Commission.
SciLifeLab Genomics and Bioinformatics (NBIS) platforms is one of the partners taking on this unique task by adding Swedish population data to this reference database and to lead the data management tasks in the project.

Key goals of the initiative include:

* **Creating a Pan-European Community of Practice**: Establishing a collaborative community to support the reference genome project.
* **Evaluate the long-term potential of genome sequencing** in research and health care in Europe and beyond, including different sequencing technologies, including long read sequencing helping to uncover previously inaccessible "dark regions" of the genome.
* **Ethics, Data Security, and Legal Compliance**: The project will be guided by ethical, legal, and societal considerations while upholding stringent data security standards building (inter)national guidelines for the responsible use of WGS that leads to better healthcare for EU citizens.
* **Embedding GoE Data within Europe’s Genomic Data Infrastructure**: Integrating GoE data into the previously funded Digital Europe Programme’s [Genomic Data Infrastructure (GDI) project](https://gdi.onemilliongenomes.eu/), ensuring interoperability across initiatives.
* **Assessing GoE’s Impact and Usability**: Through case studies, evaluating the project’s contributions to understanding genetic diversity, enabling multi-ancestry imputation, and enhancing genetic risk profiling.

**Sweden’s contribution to GoE** 

In Sweden, the GoE project has received national co-funding from Vinnova. This support will facilitate the analysis of at least 1,000 individuals using the latest long-read sequencing technologies. Samples will be sourced from the population-based biobank SCAPIS, creating a unique dataset for research, innovation, and healthcare.

* This is a fantastic opportunity to construct a new Swedish genomics resource based on long-read sequencing, a method that for the first time gives a complete view of the human genome, as well as epigenetic information, says Adam Ameur, associate professor at SciLifeLab National Genomics Infrastructure and Uppsala University.

The GoE data will be used not only for research but also as a reference dataset to improve future patient care.

* The Genome of Europe is a clinically significant project that will deepen our understanding of the human genome and its variations. This advancement will result in more patients with genetic diseases receiving accurate diagnoses, says Anna Lindstrand, Professor of Clinical Genetics at Karolinska Institutet and Chief Physician at Karolinska University Hospital.

A key aspect of the project involves making genomic data from participating European countries accessible through the new GDI infrastructure for sensitive data.

* Sweden leads the coordination of data submission into the technical infrastructure, making the description of the data discoverable and the data accessible to authorized users through secure processes, for the benefit of European citizens, says Anna Hagwall, project manager and head of human data at the SciLifeLab Bioinformatics platform NBIS.

**For Additional Information, Please Contact:**

adam.ameur@igp.uu.se, anna.lindstrand@ki.se, bengt.persson@icm.uu.se, anna.hagwall@icm.uu.se 

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Genome of Europe launched

Note! As of 2023, this support track is also open to projects involving cryo-EM applications (potentially combined with other structural biology and structure prediction methods)!

Background: One of the national services offered by NBIS/SciLifeLab is the Bioinformatics Peer review Support track (a.k.a. WABI), providing competence in large-scale data analysis for genomics, transcriptomics, proteomics, metabolomics, Cryo-EM/ET and other technologies. This support has been enabled by funding from the Knut and Alice Wallenberg Foundation, and is a part of the SciLifeLab & Wallenberg National Program for Data-Driven Life Science. We offer a senior bioinformatician to work on your project for up to 500 hours. The support is fully subsidized and free of charge, but extensive hands-on involvement is required by the applying research groups. More information along with the application form is found at the online submission here: https://www.nbis.se/services/bioinformatics/peerreview/apply 

For further questions, please do not hesitate to get in touch with the Bioinformatics support directly at bioinformatics_wabi@scilifelab.se. Also note that the NBIS platform provides bioinformatics support in several different tracks as outlined here: https://www.nbis.se/get-support

For technical questions regarding cryo-EM, please also refer to the SciLifeLab cryo-EM units:
https://www.scilifelab.se/units/cryo-em/

Apply now! October 10th: Bioinformatics Support, Peer review track (including Cryo-EM)

[The SciLifeLab and Wallenberg National Program for Data-Driven Life Science (DDLS)](https://www.scilifelab.se/wp-content/uploads/2023/03/DDLS-strategy-v2.pdf) is building the [SciLifeLab Data Platform](https://www.scilifelab.se/data-driven/data-platform/), a hub for data-driven life science research. The Data Platform offers resources and services that promote the exchange and reuse of scientific outputs (e.g. data, code, methods) in accordance with the Open Science and [FAIR](https://www.go-fair.org/fair-principles/) principles. The [four Data Science Nodes (DSNs)](https://www.scilifelab.se/news/ddls-data-science-nodes-to-be-launched) within the DDLS program contribute services, resources, and best practice guidance relevant to their scientific area to the Data Platform.

The **Data Science Node in Evolution and Biodiversity (DSN-EB)**, hosted by Uppsala University and the Swedish Museum of Natural History, is now seeking input from the community to identify priorities for its operations.
We invite you to submit a **brief, three-page proposal** on the **national data services needed in the field of evolution and biodiversity**. This is your opportunity to help advance Swedish data-driven life sciences and make a lasting impact on national data services in this research area.

**Important information**
Proposal requirements can be found in the PDF file linked below. Submit your proposal as a PDF file to this email: dsn-eb@scilifelab.se
**Deadline for submission: September 15th, 2024, at midnight CET**

Please note that this is the first of many opportunities to share your ideas about national data services with us.
Feel free to contact us to discuss your ideas for this or future needs inventories. We are here to support the evolution and biodiversity community in Sweden.

**Contact information**
Data Science Node in Evolution and Biodiversity, email: dsn-eb@scilifelab.se

[Instructions](https://www.nbis.se/wwwadmin/uploads/Instructions_DSN_EB_needs_inventory_20240823_c46cbec0db.pdf)



Inventory of needs for DDLS Evolution and Biodiversity

The event was very successful with many interesting presentations, including Mathias Uhlén presenting the Human Protein Atlas, and workshops with numerous fruitful discussions.
More info about ELIXIR All Hands Meetings at: https://elixir-europe.org/events/all-hands

Photo: Mikael Wallerstedt

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ELIXIR All Hands Meeting 2024

Apply now! May 2nd: Bioinformatics Support, Peer review track (including Cryo-EM)

FEGA Sweden provides access to human genomic data for academic researchers in biomedicine. FEGA is based on data being submitted into a national node while the metadata is entered into a central function, called EGA, where researchers can search for metadata and, upon approval, securely access data. Approved ethical permissions are required to submit and access data. Additionally, the data controller must approve the applicant's project description for encrypted data to be made accessible. NBIS developed the technology in collaboration with other Nordic countries as part of the NeIC Tryggve projects. [https://neic.no/heilsa/](link) 

A pilot project with the Swedish Childhood Tumour Biobank (Barntumörbanken) has been completed. We now continue to work through the waiting list of about 20 research groups' data and open the doors for new research groups.

[News at Uppsala University](https://www.uu.se/en/news/archive/2024-02-26-easier-to-share-genomic-data-between-countries)  
[FEGA Sweden Website](https://fega.nbis.se)

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NBIS provides secure sharing of genomic data

NEW! As of 2023, this support track is also open to projects involving cryo-EM and cryo-ET applications (potentially combined with other structural biology and structure prediction methods)!

Background: One of the national services offered by NBIS/SciLifeLab is the Bioinformatics Peer review Support track (a.k.a. WABI), providing competence in large-scale data analysis for genomics, transcriptomics, proteomics, metabolomics, Cryo-EM/ET and other technologies. This support has been enabled by funding from the Knut and Alice Wallenberg Foundation, and is a part of the SciLifeLab & Wallenberg National Program for Data-Driven Life Science. We offer a senior bioinformatician to work on your project for up to 500 hours. The support is fully subsidized and free of charge, but extensive hands-on involvement is required by the applying research groups. For more information along with the application form is found at the online submission here: https://www.nbis.se/services/bioinformatics/peerreview/apply 
For further questions, please do not hesitate to get in touch with the Bioinformatics support directly at bioinformatics_wabi@scilifelab.se. Also note that the NBIS platform provides bioinformatics support in several different tracks as outlined here: https://www.nbis.se/get-support

For technical questions regarding cryo-EM/ET, please also refer to the SciLifeLab cryo-EM units:
https://www.scilifelab.se/units/cryo-em/

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Apply now! Feb 2: Bioinformatics Support, Peer review track (including Cryo-EM/ET!)

**Preliminary Programme**

0930–1000 Coffee/Tea

1000–1015 Bengt Persson: Welcome and NBIS overview 
1015–1100	_Keynote presentation_ by Mathias Uhlén: Human Protein Atlas (HPA) 
1100–1115	Björn Nystedt: WABI 10 years 
1115–1135	User presentation by Anna Rising and Johan Reimegård: Blueprint behind natures high-performance fiber 
1135–1155	User presentation by Maria Ulvmar: Automatic detection of vascular remodeling in cancer

1200–1300	Lunch

1300–1305	Joel Hedlund: AIDA Data Hub 
1305–1350	_Keynote presentation_ by Jeroen van der Laak: Bigpicture and Digital pathology 
1350–1400	Anna Hagwall: Human data 
1400–1420	User presentation by Andreas Wallberg: Adaptation under the Sea: new insights into ecological genomics in keystone zooplankton 
1420–1430	Niclas Jareborg: Data management – FAIR data for Swedish research

1430–1500	Coffee/Tea

1500–1530	User presentation by Johan Lindberg: Addressing precision medicine challenges in cancer 
1530–1540	Jessica Lindvall: Advanced training 
1540–1550	Jonas Söderberg: Support for Computational Resources 
1550–1600	Bengt Persson: Concluding remarks 

1600 – 	Drinks and finger food

Please **register** via this link: 
[https://nbis.typeform.com/to/APxNTFbl
] 
so that we know approximately how many that will attend.

Welcome!

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NBIS Anniversary Symposium 24th of November

NEW! As of 2023, this support track is also open to projects involving cryo-EM and cryo-ET applications (potentially combined with other structural biology and structure prediction methods)!

Background: One of the national services offered by NBIS/SciLifeLab is the Bioinformatics Peer review Support track (a.k.a. WABI), providing competence in large-scale data analysis for genomics, transcriptomics, proteomics, metabolomics, Cryo-EM/ET and other technologies. This support has been enabled by funding from the Knut and Alice Wallenberg Foundation, and is a part of the SciLifeLab & Wallenberg National Program for Data-Driven Life Science. We offer a senior bioinformatician to work on your project for up to 500 hours. The support is fully subsidized and free of charge, but extensive hands-on involvement is required by the applying research groups. For more information along with the application form is found at the online submission here: https://www.nbis.se/services/bioinformatics/peerreview/apply 
For further questions, please do not hesitate to get in touch with the Bioinformatics support directly at bioinformatics_wabi@scilifelab.se. Also note that the NBIS platform provides bioinformatics support in several different tracks as outlined here: http://www.nbis.se/support/

For technical questions regarding cryo-EM/ET, please also refer to the SciLifeLab cryo-EM units:
https://www.scilifelab.se/units/cryo-em/

Apply now! Bioinformatics Peer review Support track (now including Cryo-EM/ET!)





Details of the position and the recruitment process are given in the vacancy announcement, the key steps are:

The applications will be considered by the Director Search Committee in mid-August
Longlisted candidates will be invited to interview with Perrett Laver in late August
Director Search Committee will subsequently meet to decide upon a shortlist in early September and will proceed with first round interviews during w/c 11th September.  Final interviews will take place in the first half of October.

Niklas Blomberg, ELIXIR’s founding Director, announced his departure in April, after 10 years with ELIXIR. He will be leaving at the end of 2023 to become Executive Director of the Innovative Health Initiative, based in Brussels.

**The deadline for applications is 9am BST on Monday 7th August 2023.**

For an informal and confidential discussion about the role, please contact Tadhg Waddington on +44 (0)207340 7369 or by sending an email to tadhg.waddington@perrettlaver.com.

View vacancy announcement: https://candidates.perrettlaver.com/vacancies/3698/director/

Download the vacancy brochure: https://elixir-europe.org/system/files/elixir-director-candidate-brochure.pdf

ELIXIR Director recruitment opens

Karolinska University Hospital in Sweden now offers routine diagnostic testing of cell-free DNA in patients with metastatic prostate cancer. The test is the result of a long collaboration between Johan Lindberg’s team and Scilifelab platforms (Clinical Genomics and NBIS) in the ProBio prospective clinical trial study. ([Read more](https://www.scilifelab.se/news/precision-medicine-diagnostic-test-for-metastatic-prostate-cancer-transitions-from-research-to-application/?utm_campaign=nyhetsbrev&utm_medium=email&utm_source=apsis).)

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NBIS contributes to clinical application of diagnostic test for prostate cancer

In time for our 15 years’ anniversary, NBIS updates its face to the world. We have created an modern, refreshed website meeting the needs of our users. While we will continue to add functionality and information, we now release a first version of the new NBIS website.

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NBIS new website released

It is 15 years since BILS, the first embryo to what would become NBIS, was initiated. Four years later, 2012, saw the formation of a second Swedish bioinformatics infrastructure, WABI. 

For a couple of years, the two infrastructures lived side by side, but in 2016 they merged and became NBIS, the Scilifelab bioinformatics platform. In 2021, the platform was joined by the AIDA Data Hub and BIIF forming the NBIS we have today, a multidisciplinary and important infrastructure for Swedish Life Science. 

We of course plan to celebrate our 15 years in various ways during 2023. Keep your eyes open for more upcoming info at a website near you.

News Archive