Louella Vasquez

Louella Vasquez NBIS expert

Genomics, Epigenetics, Integrative omics, Genetic association studies, Statistical analysis


Louella has a Phd in Physics from the University of Warwick in the UK. She then joined the Wellcome Trust Sanger Institute as a Postdoc in the human genetics department and eventually held a Staff Scientist position. She has also worked in a Cambridge liquid biopsy diagnostics company as a Senior Data Scientist.

Over the years, she has been analysing multiomics data (transcriptomics, ChIPseq, DNA methylation, WGS) and integrating genetics to genomics in human complex traits and diseases. Her passion is to understand molecular pathways that could explain disease mechanism with the aim to identify biomarkers for potential therapeutic targets. She is also interested in gene regulatory pathways that are crucial for stem cell development towards lineage specification.

Louella joined the NBIS Long Term Support in February 2020 and is largely involved in multiomics projects.

Selected publications

Kundu, K., Mann, A. L., Tardaguila, M., Watt, S., Ponstingl, H., Vasquez, L., Morrell, N. W., Stegle, O., Pastinen, T., Sawcer, S. J., Anderson, C. A., Walter, K., and Soranzo, N. (2020) Genetic associations at regulatory phenotypes improve fine-mapping of causal variants for twelve immune-mediated diseases.

Watt, S., Vasquez, L., Walter, K., Mann, A. L., Kundu, K., Chen, L., Yan, Y., Ecker, S., Burden, F., Farrow, S., Farr, B., Iotchkova, V., Elding, H., Mead, D., Tardaguila, M., Ponstingl, H., Richardson, D., Datta, A., Flicek, P., Clarke, L., Downes, K., Pastinen, T., Fraser, P., Frontini, M., Javierre, B.-M., Spivakov, M., and Soranzo, N. (2021) Genetic perturbation of PU1 binding and chromatin looping at neutrophil enhancers associates with autoimmune disease. Nature Communication.

Cheung, W. A. et al. (2017) Functional variation in allelic methylomes underscores a strong genetic contribution and reveals novel epigenetic alterations in the human epigenome. Genome Biology, 18.

Chen, L. et al. (2016) Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells. Cell, 167, 1398–1414.e24.

Astle, W. J. et al. (2016) The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. Cell, 167, 1415–1429.e19.

Moreau, T., Evans, A. L., Vasquez, L., Tijssen, M. R., Yan, Y., Trotter, M. W., Howard, D., Colzani, M., Arumugam, M., Wu, W. H., Dalby, A., Lampela, R., Bouet, G., Hobbs, C. M., Pask, D. C., Payne, H., Ponomaryov, T., Brill, A., Soranzo, N., Ouwehand, W. H., Pedersen, R. A., and Ghevaert, C. (2016) Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming. Nature Communications, 7.

Vasquez, L. J., Mann, A. L., Chen, L., and Soranzo, N. (2015) From GWAS to function: lessons from blood cells. ISBT Science Series, 11, 211–219.

Chen, L. et al. (2014) Transcriptional diversity during lineage commitment of human blood progenitors. Science, 345, 1251033–1251033.

Shin, S.-Y. et al. (2014) An atlas of genetic influences on human blood metabolites. Nature Genetics, 46, 543–550.

Rodriguez, A., Vasquez, L. J., Slevin, K., and Römer, R. A. (2010) Critical Parameters from a Generalized Multifractal Analysis at the Anderson Transition. Physical Review Letters, 105.

Rodriguez, A., Vasquez, L. J., and Römer, R. A. (2009) Multifractal Analysis with the Probability Density Function at the Three-Dimensional Anderson Transition. Physical Review Letters, 102.